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Based on the pooled data across all evaluated PD-1/PD-L1 inhibitors, the eight most frequently reported respiratory adverse eventsdyspnoea, pneumonia, pneumonitis, interstitial lung disease, cough, pleural effusion, respiratory failure, and immune-mediated lung diseasewere selected to establish a common baseline for subsequent analyses
More clinical evaluations are needed to firmly establish the role of DSIP in human sleep and central nervous system disorders
The three genotypes are highly expressed in synapses before the formation of extensive synapses, with neurexin-1 and neurexin-3 widely distributed between neuronal synapses in the cortical plate, and neurexin-2 distributed between neuronal synapses in the cortical wall [66]
Uchimido R, Schmidt EP, Shapiro NI
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PMID 10027296
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